We envision a future where medicine is humane, precise, personalized and affordable.
Our mission is to serve humankind through scientific research and teaching.
Our research goal is to understand how gene networks control cell behavior. We focus on important cancer genes
and trisomy 21.
We are a research-teaching team. We teach in the classroom, in the lab and on social media.
Our integrated multi-omics analysis of the p53 network is published in Genome Research and picked up by the media
September 13, 2017
After four years of hard work, we completed the most comprehensive analysis of the p53 signaling network to date, involving an integrated multi-omics analysis of p53 target genes controlled at the transcriptional, post-transcriptional and translational levels.
This was a big effort by many members of the team, including ChIP-seq, GRO-seq, RNA-seq and shRNA analyses of mutliple cell types, as well as a massive data analysis of 4000+ tumor genomes.
The key message is that p53 directly activates a core set of ~100 target genes in mutliple cellular contexts, where no single gene makes a significant contribution to p53's overall tumor suppressive activity.
The paper can be accessed freely here.
You can read a press release about the manuscript here.
On the origins of long non-coding RNAs: missing link found! Read it here.
Collaborative work with the Taatjes lab at CU-Boulder is published in MCB, reporting a kinase-independent role for CDK19 in the p53 program. Read it here.
A genetic screen leads to identitication of genetic liabilities and pharmacological strategies for MLL-rearranged leukemias. Read the paper here.
Joaquin's piece on lncRNAs is published in TIGS
Collaboration paper on CDK19 comes out in MCB
Paper in collaboration with the Shilatifard lab is published in Cell!
There is no science without fancy and no art without facts.
Awesome post-doctoral fellows wanted!
The Espinosa lab is looking for capable and motivated post-doctoral researchers interested in partaking in one of the many exciting projects in the lab. Apply at: