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70. Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation. 2017. Sullivan, K.D., Evans, D., Pandey, A., Hraha, T.H., Smith, K.P., Markham, N., Rachubinski, A.L., Wolter-Warmerdam, K., Hickey, F., Espinosa, J.M., and Blumenthal, T. Scientific Reports (in press).


69. CDK8 kinase activity promotes glycolysis. 2017. Galbraith, M.D., Andryzik, Z., Pandey, A., Hoh, M., Bonner, M.A., Hill, A., Sullivan, K.D., and Espinosa, J.M. Cell Reports (in press).


68. Mechanisms of transcriptional regulation by p53. 2017. Sullivan, K.D., Galbraith, M.D., Andrysik, Z. and Espinosa, J.M. Cell Death and Differentiation (in press).


67. Exosomal biomarkers in Down syndrome and Alzheimer's disease. Hamlett, E., Ledreux, A., Potter, H., Chial, H., Espinosa, J.M., Bettcher, B.M. and Granholm, A.C. 2017. Free Radical Biology and Medicine, epub ahead of print.


66. Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity. Andrysik, Z., Galbraith, M.D., Guarnieri, A.L., Zaccara, S., Sullivan, K.D., Pandey, A., MacBeth, M., Inga, A., and Espinosa, J.M. 2017. Genome Research 27(10):1645-1657.


65. On the evolution of lncRNAs: missing link found. Espinosa, J.M. 2017. Trends in Genetics 33(10):660-662.


64. A kinase independent role for CDK19 in p53 response. Audetat, K.A., Galbraith, M.D., Odell, A.T., Lee, T., Pandey, A., Espinosa, J.M., Dowell, R.D. and Taatjes, D.J. Molecular and Cellular Biology (2017) epub ahead of print.


63. Therapeutic targeting of MLL degradation pathways in MLL-rearranged leukemias. Liang, K., Volk, A.G., Haug, J.S., Marshall, S.A., Woodfin, A.R., Bartom, E.T., Gilmore, J.M., Florens, L., Washburn, M.P., Sullivan, K.D., Espinosa, J.M., Cannova, J., Zhang, J., Smith, E.R., Crispino, J.D., Shilatifard, A. 2017. Cell 168(1-2):59-72.




62. Multivalent chromatin engagement and inter-domain crosstalk regualte MORC3 ATPase. Andrews, F.H., Tong, Q., Sullivan, K.D., Cornett, E.M., Zhang, Y., Ali, M., Ahn, J., Pandey, A., Guo, A.H., Strahl, B.D., Costello, J.C., Espinosa, J.M., Rothbart, S.B., and Kutateladze, T.G. 2016. Cell Reports 16(12):3195-3207.  


61. Trisomy 21 consistently activates the interferon response. Sullivan, K.D., Lewis, H.C., Hill, A.A., Pandey, A., Jackson, L.P., Cabral, J.M., Smith, K.P., Liggett, L.A., Gomez, E.B., Galbraith, M.D., DeGregori, J. and Espinosa, J.M. 2016. eLIFE e16220.


60. The NSL chromatin-modifying complex subunit KANSL2 regualtes cancer stem cell-like properties in glioblastoma that contribute to tumorigenesis. Ferreyra-Solari, N., Belforte, F.S., Canedo, L., Videla-Richardson, G.A., Espinosa, J.M., Rossi, M., Serna, E., Riuvadets, M.A., Martinetto, H., Sevlever, G. and Perez-Castro, C. 2016. Cancer Research (epub ahead of print).


59. TIP60 is a conserved coactivator of HIF1A. Perez-Perri, J.L., Dengler, V.L., Audetat, A.K., Pandey, A., Bonner, E.A., Urh, M., Mendez, J., Daniels, D.L., Wappner, P., Galbraith, M.D. and Espinosa, J.M. 2016. Cell Reports 16(1):37-47.  


58. Revisiting lncRNAs: how do you know yours is not an eRNA? Espinosa, J.M. 2016. Molecular Cell 62(1):1-2.


57. NPM and BRG1 mediate transcirptional resistance to retinoic acid in acute promyelocytic leukemia. Nichol, J.M., Galbraith, M.D., Espinosa, J.M. and Miller W.H. 2016. Cell Reports 14(12):2938-49.





56. Towers, C.G., Guarnieri, A.L., Micalizzi, D.S., Harrell, J.C., Gillen, A.E., Kim, K., Wang, C.A., Oliphant, M.U.J., Drasin, D.J., Guney, M.A., Kabos, P., Sartorius, C.A., Tan, A.C., Perou, C.M., Espinosa, J.M. and Ford, H.L. 2015. The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. Nature Communications 6:10077.


55. Warren, C.J., van Dorslaer, K., Pandey, A., Espinosa, J.M., and Pyeon, D. 2015. Role of restriction factor APOBEC3 on papillomavirus evolution. Virus Evolution 1(1):vev015.


54. Abraham, C.G. and Espinosa, J.M. The crusade against mutant p53: does the COMPASS point to the Holy Grail? 2015. Cancer Cell 28(4):407-8.


53. Sullivan K.D. and Espinosa J.M. 2015. A signature for success. eLife 2015 doi: 10.7554/eLife.08773.


52. Tentler J.J., Ionkina A.A., Tan A.C., Newton T.P, Pitts T.M., Glogowska M.J., Kabos P., Sartorius C.A., Sullivan K.D., Espinosa J.M. , Eckhardt S.G. , and Diamond J.R. 2015. p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer. Molecular Cancer Therapeutics 14(5):1117-29.


51. Sullivan K.D., Nakagawa A., Xue D. and Espinosa J.M. 2015. Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells. Cell Cycle 14(12):1771-8.


50. Sullivan, K.D., Palaniappan, V.V. and Espinosa, J.M. 2015. ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels. Cell Cycle 14(1):56:63.





49. Allen, M.A., Andrysik, Z., Dengler, V.L., Mellert, H.S., Guarnieri, A., Freeman, J.A., Sullivan, K.D., Galbraith, M.D., Luo, X., Kraus, W.L., Dowell, R.D. and Espinosa, J.M. 2014. Global analysis of p53-regulated transcription reveals its direct targets and unexpected regulatory mechanisms. eLife 2014;3:e02200.


48. Thorburn, J., Andrysik, Z., Staskiewicz, L., Gump, J., Maycotte, P., Oberst, A., Green, D.R., Espinosa, J.M. and Thorburn, A. 2014. Autophagy controls the kinetics and extent of mithocondrial apoptosis by regulating PUMA levels.  Cell Reports 7(1)45-52.


47. Dengler, V.L., Galbraith, M. and Espinosa, J.M. 2014. Transcriptional regulation by hypoxia inducible factors. Critical Reviews in Biochemistry and Molecular Biology 49(1):1-15.


46. Guarnieri, A. and Espinosa, J.M. 2014. Back to bases: how a nucleotide biosynthetic enzyme controls p53 activation. Molecular Cell 53(3):365-7.





45. Nakashima, M., Nandakumar, J., Sullivan, K.D., Espinosa, J.M. and Cech, T.R. 2013. Inhibition of telomerase recruitment and cancer cell death. Journal of Biological Chemistry 288(46):33171-80.


44. Galbraith, M.D., Saxton, J., Li, L., Shelton, S., Zhang, H., Espinosa, J.M. and Shaw, P.E. 2013.  ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1. Nucleic Acid Research 41(22):10241-53.


43. Daniels, D.L., Ford, M., Schwinn , M.K., Benink, H., Galbraith, M.D., Amunugama, R., Jones, R., Allen., D, Okazaki, N., Yamakawa, H., Miki, F., Nagase, T., Espinosa, J.M. and Urh, M. 2013. Mutual exclusivity of MED12/MED12L, MED13/13L, and CDK8/19 paralogs revealed within the CDK8-Mediator kinase module. Journal of Proteomics and Bioinformatics. (epub ahead of print)


42. Mellert, H. and Espinosa, J.M. 2013. Tumor suppression by p53: is apoptosis important or not? Cell Reports 3(5):1335-6. pdf


41. Galbraith, M.D., Allen, M.A., Bensard, C.L., Wang, X., Schwinn, M.K., Qin, B., Long, H.W., Daniels, D.L., Hahn, W.C., Dowell, R.D. and Espinosa, J.M. 2013. HIF1A employs CDK8-Mediator to stimulate RNAPII elongation in response to hypoxia. Cell 153(6):1327-39. pdf


40. Andrysik, Z., Kim, J., Tan, A.C. and Espinosa, J.M. 2013. A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation. Cell Reports, 3:1-9. pdf


39. Gallant-Behm, C.L. and Espinosa, J.M. 2013. How does ∆Np63α drive cancer? Epigenomics, 5(1):5-7. pdf


38. Gallant-Behm, C.L., Espinosa, J.M. 2013. ΔNp63α utilizes multiple mechanisms to repress transcription in squamous cell carcinoma cells. Cell Cycle 12(3):409-416. pdf


37. Freeman, J.A., Espinosa, J.M. 2013. The impact of post-transcriptional regulation in the p53 network. Briefings in Functional Genomics 12(1):46-57. pdf





36. Gallant-Behm, C.L., Ramsey, M.R., Bensard, C.L., Nojek, I., Tran, J., Liu, M., Ellisen, L.W., Espinosa, J.M. 2012. ΔNp63α represses anti-proliferative genes via H2A.Z deposition. Genes and Development 26: 2325-2336. pdf


35. Smallwood, A., Hon, G.C., Jin, F., Henry, R.E., Espinosa, J.M., Ren, B. 2012. CBX3 regulates efficient RNA processing genome-wide. Genome Research 8:1426-36. pdf


34. Sullivan, K.D., Padilla-Just, N., Henry, R.E., Porter, C.C., Kim, J., Tentler, J.J., Eckhardt, S.G., Tan, A.C., Degregori, J., Espinosa, J.M. 2012. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nature Chemical Biology 8:646-654. pdf


33. Sullivan, K.D., Gallant-Behm, C.L., Henry, R., Fraikin, J.L., Espinosa, J.M. 2012. The p53 circuit board. Biochimica et Biophysica Acta Reviews in Cancer 1825(2):229-244. pdf


32. Henry, R., Andrysik, Z., Paris, R., Galbraith, M.D., Espinosa, J.M. 2012. A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. EMBO Journal 31:1266-1278. pdf


31. Espinosa, J.M. 2012. Get back TFIIF, don't let me Gdown1. Molecular Cell 45(1):3-5. pdf




30. Galbraith, M.D., Espinosa, J.M. 2011. Lessons on transcriptional control from the serum response network. Current Opinion in Genetics & Development 21(2):160-166. pdf





29. Espinosa, J.M. 2010. The meaning of pausing. Molecular Cell 40(4):507-8. pdf


28. Zhong, L., D'Urso, A., Toiber, D., Sebastian, C., Henry, R., Vadysirisack, D.D., Guimaraes, A., Marinelli, B., Wikstrom, J., Nir, T., Clish, C., Vaitheesvaran, B., Kurland, I., Dor, Y., Weissleder, R., Shirihai, O., Ellisen, L., Espinosa, J. and Mostoslavsky, R. 2010. The histone deacetylase SIRT6 regulates glucose homeostasis via HIF1a. Cell 140(2):280-293. pdf


27. Donner, A.J., Ebmeier, C.C., Taatjes, D.J., and Espinosa, J.M. 2010. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nature Structural & Molecular Biology 17(2):194-201. pdf


26. Gomes, N.P. and Espinosa, J.M. 2010. Differential regulation of p53 target genes: it's (core promoter) elementary. Genes and Development 24(2):111-114. pdf


25. Gomes, N.P. and Espinosa J.M. 2010. Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding. Genes and Development 24(10):1022-34 pdf


24. Galbraith, M.D., Donner, A.J. and Espinosa J.M. 2010. CDK8: a positive regulator of transcription. Transcription 1(1):4:12.pdf


23. Gomes, N.P. and Espinosa J.M. 2010. Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes. Cell Cycle 9(17):3428-37 pdf





22. Beckerman, R., Donner, A. J., M., Peart, M.J., Manley, J.M., Espinosa, J.M. and Prives, C. 2009. A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S phase checkpoint. Genes and Development 23(11):1364-77. pdf


21. Knuesel M.T., Meyer K.D., Donner A.J., Espinosa J.M., Taatjes D.J. 2009.The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of Mediator. Molecular and Cellular Biology 29(3):650-61. pdf





20. Glover-Cutter, K., Kim, S., Espinosa, J. and Bentley, D.L. 2008. RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes. Nature Structural & Molecular Biology 15(1):71-78. pdf


19. Espinosa, J.M. 2008. Mechanisms of regulatory diversity within the p53 transcriptional network. Oncogene 27(29):4013-23. pdf


18. Meyer, K.D., Donner, A.J., Knuesel, M.T., York, A.G., Espinosa J.M., Taatjes, A.D. 2008. Cooperative activity of CDK8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO Journal 27(10):1447-57. pdf


17. Wade, M., Rodewald, L.W., Espinosa, J.M. and Wahl, G.M. 2008. BH3 activation overcomes Hdmx suppression of apoptosis and co-operates with Nutlin to induce cell death. Cell Cycle 7(13):1973-82. pdf


16. Paris, R., Henry, R.E., Stephens, S.J., McBryde, M. and Espinosa, J.M. 2008. Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation. Cell Cycle 7(15):2427-33. pdf


15. Espinosa, J.M. Histone H2B ubiquitination: the cancer connection. 2008. Genes and Development 22(20):2743-9. pdf





14. Donner, A.J., Szostek, S., Hoover, J.M. and Espinosa, J.M. 2007. CDK8 is a stimulus-specific positive coregulator of p53 target genes. Molecular Cell 27(1):121-33. pdf


13. Kalet, B.T., McBryde, M., Espinosa, J.M. and Koch, T. 2007. Doxazolidine induction of apoptosis by a topoisomerase II-independent mechanism. Journal of Medicinal Chemistry 50(18):4493-500, 2007. pdf


12. Donner, A.J., Hoover, J.M., Szostek, S. and Espinosa, J.M. 2007. Stimulus-specific transcriptional regulation within the p53 network. Cell Cycle 6(21):2594-2598. pdf



2006 & earlier


11. Gomez, E.B., Espinosa, J.M., and Forsburg, S.L. 2005. Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing. Molecular and Cellular Biology 25(20):8887-903.


10. Gomes, N., Bjerke, G., Llorente, B., Szostek, S., Emerson, B.M., and Espinosa, J.M. 2006. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes and Development 20:601-612.


9. Espinosa, J. M., Verdún, R. E., and Emerson, B. M. 2003. p53 functions through stress- and promoterspecific recruitment of transcription initiation components before and after DNA damage. Molecular Cell 12:1015-1027.


8. Espinosa, J. M., Verdún, R. E., and Emerson, B. M. 2003. p53 functions through stress- and promoterspecific recruitment of transcription initiation components before and after DNA damage. Molecular Cell 12:1015-1027. pdf


7. Espinosa, J. M., Portal, D., Lobo, G. S., Pereira, C. A., Alonso, G. D., Gómez, E. B., Humbert-Lan, G., Rivera-Pomar, R. V., Flawiá, M. M., and Torres, H. N. 2003.  Trypanosoma cruzi Poly Zinc Finger Protein:  a novel DNA/RNA-binding CCHC-Zinc Finger Protein. Molecular and Biochemical Parasitology 131:35-44.


6. Portal, D., Espinosa, J. M., Lobo, G.D., Kadener, S., Pereira, C. A., De La Mata, M., Tang, Z., Lin, R. J., Kornblihtt, A. R., Baralle, F. E., Flawiá, M. M., and Torres, H. N.  2003.  An early ancestor in the evolution of splicing:  a Trypanosoma cruzi serine-arginine-rich protein (TcSR) is functional in cis-splicing. Molecular and Biochemical Parasitology 127:37-46.


5. Portal, D., Lobo, G. S., Kadener, S., Prasad, J., Espinosa, J. M., Pereira, C. A., Tang, Z., Lin, R. J., Manley, J. L., Kornblihtt, A. R., Flawiá, M. M. and Torres, H. N. 2003.  Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases. Molecular and Biochemical Parasitology 127:9-21.


4. Diaz Anel, A., Rossi, S. M., Espinosa, J. M., Guida, C., Freitas, F. A., Kornblihtt, A. R., Zingales, B., Flawiá, M. M., and Torres, H. N.  2000.  mRNA encoding a putative RNA Helicase of the DEAD-box Gene Family is up-regulated in Trypomastigotes of Trypanosoma cruzi.  The Journal of Eukaryotic Microbiology 47:555-60.


3. Espinosa, J. M., Martinetto, H., Portal, D., D’Angelo, M., Torres, H. and Flawia, M. M.  1999. Factors from Trypanosoma cruzi interacting with AP-1 sequences. The Journal of Eukaryotic Microbiology 46:516-521.


2. Pereira, C., Paveto, C., Espinosa, J.M., Alonso, G., Flawia, M. M., and Torres, H. N.  1997. The control of Trypanosoma cruzi epimastigote motility through the nitric oxide pathway. The Journal of Eukaryotic Microbiology 44:155-156.


1. Paveto, C., Pereira, C., Espinosa, J.M., Montagna, A., Farber, M., Flawiá, M. M., and Torres, H. N. 1995. The Nitric Oxide transduction pathway in Trypanosoma cruzi. The Journal of Biological Chemistry 270:16756-16579.